• About Us
  • Terms & Conditions
  • Contact Us
Sunday, March 7, 2021
Investogist
No Result
View All Result
  • Home
  • News
    • All
    • Africa
    • Nigeria
    • World
    Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

    Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

    Nestle Nigeria Plc announces Board meeting to consider 2020 accounts and dividend

    Nestle Nigeria Plc issues notice of AGM

    FG approves 39 licences for fish importation

    FG approves 39 licences for fish importation

    Nigeria has 2.5m metric tonnes of fish deficit — Minister

    Nigeria has 2.5m metric tonnes of fish deficit — Minister

    Updated: AstraZeneca–Oxford Covid-19 vaccine arrives Nigeria

    Updated: AstraZeneca–Oxford Covid-19 vaccine arrives Nigeria

    NNPC says no plan to increase petrol price in March

    NNPC says no plan to increase petrol price in March

    JPMorgan endorses 1% portfolio allocation to Bitcoin as a hedge

    JPMorgan endorses 1% portfolio allocation to Bitcoin as a hedge

    Zoom Video Communications Inc extends losing streak to day 7

    Zoom Video Communications Inc extends losing streak to day 7

    Gamestop rally due to institutional speculative option bets

    Gamestop rally due to institutional speculative option bets

    • Nigeria
    • Africa
    • World
  • Economy
    • All
    • Budgets
    • Economic Data
    • Policies
    Okonjo-Iweala, WTO and Nigeria: Internal Worries

    Okonjo-Iweala, WTO and Nigeria: Internal Worries

    Nigeria raises borrowing limit in New Debt Management Plan

    DMO delivers new plan for debt management, amid rising fiscal pressures

    Fixed Income Market: Special Bills Drifts the Market in Search of Direction

    Domestic Economy: A Glimmer of Hope…as Surprise Growth in GDP Stimulates Economy out of Recession

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    Nigeria’s Inflation rate hits16.47%, the highest since May 2017

    Nigeria’s Inflation rate hits16.47%, the highest since May 2017

    All diaspora remittances must be received by beneficiaries in foreign currency only – CBN

    FG and States allocations in 2020

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain (Continued)

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Nigeria raises borrowing limit in New Debt Management Plan

    Nigeria raises borrowing limit in New Debt Management Plan

    • Policies
    • Budgets
    • Economic Data
  • Markets
    • All
    • Commodities
    • Cryptocurrencies
    • Forex
    • Rates & Bonds
    • Stocks/Equities
    Nigerian Stock Market Daily Report: Investors lose N277.597 Billion as sell-off continues

    Stocks Fall for Fifth-Straight Week, Industrial Goods Sector Emerges Lone Gainer in Week

    List of Dividends announced in 2021, qualification and payment dates

    List of Dividends announced in 2021, qualification and payment dates

    Sunny Anene raises his stake in United Capital Plc

    Dennis Olisa raises his stake in Zenith Bank Plc

    Total transaction on the Nigerian Bourse declined by 13.7% MoM

    Total transaction on the Nigerian Bourse declined by 13.7% MoM

    Nigerian Stock Market Daily Report: Investors lose N277.597 Billion as sell-off continues

    Local Bourse Extends Losing Streak…with All Share Index Below 40,000pts

    Fixed Income Market: Tide Remains Bleak in the Fixed Income Market

    Fixed Income Market: Rates Persist on a Piecemeal Shift

    Sunny Anene raises his stake in United Capital Plc

    Sunny Anene raises his stake in United Capital Plc

    GameStop surges 104% as buying frenzy resumes

    GameStop surges 104% as buying frenzy resumes

    Tesla suffers biggest loss in 5 months amid Bitcoin slump

    Tesla suffers biggest loss in 5 months amid Bitcoin slump

    • Stocks/Equities
    • Forex
    • Rates & Bonds
    • Commodities
    • Cryptocurrencies
  • Business
    • All
    • Agriculture
    • Companies
    • Industry
    • Technology
    2.5m Metric Tonnes of Fish Deficit: Options from Ondo and Delta States

    2.5m Metric Tonnes of Fish Deficit: Options from Ondo and Delta States

    Here is when Seplat will release 2020 full year audited financial results

    FY 2020: Seplat reports over N30 billion loss as revenue declines

    Now that Eto Has Cleared Apapa Roads

    Now that Eto Has Cleared Apapa Roads

    Nestle Nigeria Plc announces Board meeting to consider 2020 accounts and dividend

    FY 2020: Nestle Nigeria Plc reports 14% decline in profit

    Coinbase to list on Nasdaq by Introduction, cites bitcoin founder(s) as risk factor

    Coinbase to list on Nasdaq by Introduction, cites bitcoin founder(s) as risk factor

    FY 2020: Zenith Bank Plc rakes in N230.6 billion profit after tax

    FY 2020: Zenith Bank Plc rakes in N230.6 billion profit after tax

    AGM suspension: Oando’s shareholder wins court case against SEC

    AGM suspension: Oando’s shareholder wins court case against SEC

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    FY 2020: United Capital Plc reports impressive growth in revenue, profit and assets

    Resolutions passed at Africa Prudential Plc’s Board of Directors meeting

    Resolutions passed at Africa Prudential Plc’s Board of Directors meeting

    • Companies
    • Industry
    • Technology
  • Sports
    • Football
  • Opinion & Analysis
    • All
    • Columnists
    • Editorials
    • Investogist Business Saturday
    • Op-ed
    Coronavirus Update – Chinese Vaccine Developers Lack Qualified Patients, as Nigeria Confirms 196 new cases.

    COVID-19: Pregnant women pass protective antibodies to their babies

    Fixed Income Market: Tide Remains Bleak in the Fixed Income Market

    Fixed Income Market: Naira Continues to Wobble at the I&EW

    CBN Revises Timeline for Resolving Failed ATM, PoS and Web Transactions.

    CBN keeps in place Forbearance for Credit Facilities, Monitors Economic Recovery

    Brent rises above $60 per barrel as oil rally continues

    Oil Price Jolts Up as OPEC+ Maintains Production Output for April 2021

    On that Misguided Food Blockade

    On that Misguided Food Blockade

    Scientists develop a vaccine strategy for treating urinary tract infections

    Scientists develop a vaccine strategy for treating urinary tract infections

    Jim Ovia set to receive over N12bn in dividend from Zenith Bank Plc

    Jim Ovia set to receive over N12bn in dividend from Zenith Bank Plc

    Investogist Business Saturday – Financial Ratios

    Financial ratios: Efficiency ratios explained

    Financial Ratios: Liquidity and Leverage Ratios

    Financial Ratios: Liquidity and Leverage Ratios

    • Editorials
    • Book Club
    • Investogist Business Saturday
    • Op-ed
  • Financial Education
  • Vacancies
  • Home
  • News
    • All
    • Africa
    • Nigeria
    • World
    Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

    Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

    Nestle Nigeria Plc announces Board meeting to consider 2020 accounts and dividend

    Nestle Nigeria Plc issues notice of AGM

    FG approves 39 licences for fish importation

    FG approves 39 licences for fish importation

    Nigeria has 2.5m metric tonnes of fish deficit — Minister

    Nigeria has 2.5m metric tonnes of fish deficit — Minister

    Updated: AstraZeneca–Oxford Covid-19 vaccine arrives Nigeria

    Updated: AstraZeneca–Oxford Covid-19 vaccine arrives Nigeria

    NNPC says no plan to increase petrol price in March

    NNPC says no plan to increase petrol price in March

    JPMorgan endorses 1% portfolio allocation to Bitcoin as a hedge

    JPMorgan endorses 1% portfolio allocation to Bitcoin as a hedge

    Zoom Video Communications Inc extends losing streak to day 7

    Zoom Video Communications Inc extends losing streak to day 7

    Gamestop rally due to institutional speculative option bets

    Gamestop rally due to institutional speculative option bets

    • Nigeria
    • Africa
    • World
  • Economy
    • All
    • Budgets
    • Economic Data
    • Policies
    Okonjo-Iweala, WTO and Nigeria: Internal Worries

    Okonjo-Iweala, WTO and Nigeria: Internal Worries

    Nigeria raises borrowing limit in New Debt Management Plan

    DMO delivers new plan for debt management, amid rising fiscal pressures

    Fixed Income Market: Special Bills Drifts the Market in Search of Direction

    Domestic Economy: A Glimmer of Hope…as Surprise Growth in GDP Stimulates Economy out of Recession

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    Nigeria’s Inflation rate hits16.47%, the highest since May 2017

    Nigeria’s Inflation rate hits16.47%, the highest since May 2017

    All diaspora remittances must be received by beneficiaries in foreign currency only – CBN

    FG and States allocations in 2020

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain (Continued)

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Irreconcilable Incongruities (3) – Brain Drain vs Brain Gain

    Nigeria raises borrowing limit in New Debt Management Plan

    Nigeria raises borrowing limit in New Debt Management Plan

    • Policies
    • Budgets
    • Economic Data
  • Markets
    • All
    • Commodities
    • Cryptocurrencies
    • Forex
    • Rates & Bonds
    • Stocks/Equities
    Nigerian Stock Market Daily Report: Investors lose N277.597 Billion as sell-off continues

    Stocks Fall for Fifth-Straight Week, Industrial Goods Sector Emerges Lone Gainer in Week

    List of Dividends announced in 2021, qualification and payment dates

    List of Dividends announced in 2021, qualification and payment dates

    Sunny Anene raises his stake in United Capital Plc

    Dennis Olisa raises his stake in Zenith Bank Plc

    Total transaction on the Nigerian Bourse declined by 13.7% MoM

    Total transaction on the Nigerian Bourse declined by 13.7% MoM

    Nigerian Stock Market Daily Report: Investors lose N277.597 Billion as sell-off continues

    Local Bourse Extends Losing Streak…with All Share Index Below 40,000pts

    Fixed Income Market: Tide Remains Bleak in the Fixed Income Market

    Fixed Income Market: Rates Persist on a Piecemeal Shift

    Sunny Anene raises his stake in United Capital Plc

    Sunny Anene raises his stake in United Capital Plc

    GameStop surges 104% as buying frenzy resumes

    GameStop surges 104% as buying frenzy resumes

    Tesla suffers biggest loss in 5 months amid Bitcoin slump

    Tesla suffers biggest loss in 5 months amid Bitcoin slump

    • Stocks/Equities
    • Forex
    • Rates & Bonds
    • Commodities
    • Cryptocurrencies
  • Business
    • All
    • Agriculture
    • Companies
    • Industry
    • Technology
    2.5m Metric Tonnes of Fish Deficit: Options from Ondo and Delta States

    2.5m Metric Tonnes of Fish Deficit: Options from Ondo and Delta States

    Here is when Seplat will release 2020 full year audited financial results

    FY 2020: Seplat reports over N30 billion loss as revenue declines

    Now that Eto Has Cleared Apapa Roads

    Now that Eto Has Cleared Apapa Roads

    Nestle Nigeria Plc announces Board meeting to consider 2020 accounts and dividend

    FY 2020: Nestle Nigeria Plc reports 14% decline in profit

    Coinbase to list on Nasdaq by Introduction, cites bitcoin founder(s) as risk factor

    Coinbase to list on Nasdaq by Introduction, cites bitcoin founder(s) as risk factor

    FY 2020: Zenith Bank Plc rakes in N230.6 billion profit after tax

    FY 2020: Zenith Bank Plc rakes in N230.6 billion profit after tax

    AGM suspension: Oando’s shareholder wins court case against SEC

    AGM suspension: Oando’s shareholder wins court case against SEC

    Nigeria exits recession as GDP grew for the first time in 3 quarters

    FY 2020: United Capital Plc reports impressive growth in revenue, profit and assets

    Resolutions passed at Africa Prudential Plc’s Board of Directors meeting

    Resolutions passed at Africa Prudential Plc’s Board of Directors meeting

    • Companies
    • Industry
    • Technology
  • Sports
    • Football
  • Opinion & Analysis
    • All
    • Columnists
    • Editorials
    • Investogist Business Saturday
    • Op-ed
    Coronavirus Update – Chinese Vaccine Developers Lack Qualified Patients, as Nigeria Confirms 196 new cases.

    COVID-19: Pregnant women pass protective antibodies to their babies

    Fixed Income Market: Tide Remains Bleak in the Fixed Income Market

    Fixed Income Market: Naira Continues to Wobble at the I&EW

    CBN Revises Timeline for Resolving Failed ATM, PoS and Web Transactions.

    CBN keeps in place Forbearance for Credit Facilities, Monitors Economic Recovery

    Brent rises above $60 per barrel as oil rally continues

    Oil Price Jolts Up as OPEC+ Maintains Production Output for April 2021

    On that Misguided Food Blockade

    On that Misguided Food Blockade

    Scientists develop a vaccine strategy for treating urinary tract infections

    Scientists develop a vaccine strategy for treating urinary tract infections

    Jim Ovia set to receive over N12bn in dividend from Zenith Bank Plc

    Jim Ovia set to receive over N12bn in dividend from Zenith Bank Plc

    Investogist Business Saturday – Financial Ratios

    Financial ratios: Efficiency ratios explained

    Financial Ratios: Liquidity and Leverage Ratios

    Financial Ratios: Liquidity and Leverage Ratios

    • Editorials
    • Book Club
    • Investogist Business Saturday
    • Op-ed
  • Financial Education
  • Vacancies
No Result
View All Result
Investogist
No Result
View All Result
Home Opinion & Analysis Columnists

A promising Drug against pancreatic and breast cancer 

Saturday, 13 February 2021, 5:57 pm
in Columnists, Opinion & Analysis
0
A promising Drug against pancreatic and breast cancer 
Share Share Share Share Send as Email

ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team is effective at treating pancreatic cancer and prolonged survival according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatalogy.

A second study published in the journal of experimental medicine shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis.

ProAgio, created from a human protein targets the cell surface receptor integrin which is expressed on cancer-associated fibroblasts. Fibroblasts are cells that generate collagen and other fibrous molecules and can be mobilized into service by a tumour creating a thick physical barrier known as the stroma which protects cancer and helps it grow. The drug works by inducing apoptosis or programmed cells death in cancer-associated fibroblasts that Express integrin.

Read: HEPATITIS: New discovery on hepatitis and it’s cure.

The dense fibroid stroma is what makes pancreatic cancer which has a five years survival rate of just eight percent, so lethal and difficult to treat.  Among triple-negative breast cancer patients research shows denser stroma is associated with poorer survival and high recurrence rates.

Liu said, all solid tumour use cancer-associated fibroblasts but in pancreatic cancer and triple-negative breast cancer, the stroma is so dense there’s often no way for conventional drugs to penetrate it and effectively treat cancer.

The stroma also helps the tumour hide from your body’s immune system; Immunotherapy, a type of treatment that uses your immune system to fight cancer is less effective against tumours protected by a dense stroma that is rich in cancer-associated fibroblasts.

Cancer-associated fibroblasts promote angiogenesis or the development of new blood vessels, Angiogenesis plays an important role in the spread of cancer because solid tumours need a blood supply to grow in both studies, Liu and his team show ProAgio has a profound effect on tumours vasculature in the case of pancreatic cancer, it reopened blood vessels that had collapsed due to high extravascular stress caused by the dense stroma in the case of triple-negative breast cancer. The drugs anti-angiogenic activity reduced irregular leaky angiogenic tumour vessels. In both cases, ProAgio allowed drugs to effectively reach cancer.

Liu’s drug is unique in that it targets only cancer-associated fibroblasts- a subclass of the cells that are actively engaged in supporting cancer rather than inactive fibroblasts, this reduces side effects of the drug and increases its effectiveness.

“When you have a wound, for example, normal fibroblasts will secrete fibres to limit the damage and promote healing,” said Liu. “The tumour region is basically a wound that won’t heal.  Quiescent Fibroblasts may play a role in preventing cancer from spreading; you don’t want to kill the good guys only the bad guys” he added.

ProAgio is licensed to ProDa Bio Tech, a pharmaceutical research company founded by Liu in 2018.  ProDa Bio Tech received $2 million from the National Cancer Institute to fund toxicology and pharmacokinetics studies that are required before moving the drugs to early-stage clinical trials. Those studies have been completed and the company has submitted an Investigational New Drugs (IND) Application, a request for authorization from the Food and Drug Administration to administer ProAgio to human subjects.

Once the IND is granted, Liu says the immediate next step is to begin clinical trials, The first trial is to determine patients tolerability and recommends phase if dose, will begin in early 2021 at the National Institute of Health Clinical Centre in Bethesda, Mdi and will be led by Christine Alewine M.D  an oncologist at the National Cancer Institute in late 2021, Emory University is set to begin a multi-site trial among breast cancer and pancreatic cancer patient.

By: Peace Chigozie

Previous Post

Ogoni People can sue Royal Dutch Shell in English Courts – UK’s Supreme Court

Next Post

Morgan Stanley unit considers $150 Billion investment in Bitcoin

Next Post
Morgan Stanley unit considers $150 Billion investment in Bitcoin

Morgan Stanley unit considers $150 Billion investment in Bitcoin

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

  • Trending
  • Comments
  • Latest
List of Dividends announced in 2021, qualification and payment dates

List of Dividends announced in 2021, qualification and payment dates

Blachowicz Ends Israel Adesanya’s 20-Fight Unbeaten Run

Blachowicz Ends Israel Adesanya’s 20-Fight Unbeaten Run

Rangers Win Scottish Premiership with Balogun and Aribo

Rangers Win Scottish Premiership with Balogun and Aribo

NIGERIA TRADEMARK OIL – BONNY LIGHT SLUMPS TO $12 /Barrel

Just in: NNPC invites tenders for 2020 – 2021 Direct Sale of Crude Oil & Direct Purchase of Petroleum Products

Nigerian Stock Market Daily Report: Investors lose N277.597 Billion as sell-off continues

Stocks Fall for Fifth-Straight Week, Industrial Goods Sector Emerges Lone Gainer in Week

Rangers Win Scottish Premiership with Balogun and Aribo

Rangers Win Scottish Premiership with Balogun and Aribo

Blachowicz Ends Israel Adesanya’s 20-Fight Unbeaten Run

Blachowicz Ends Israel Adesanya’s 20-Fight Unbeaten Run

Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

Central Bank of Nigeria introduces “CBN Naira 4 Dollar Scheme” for Diaspora remittances

Investogist
info@investogist.com

Follow us

Categories

  • Africa
  • Agriculture
  • Budgets
  • Business
  • Columnists
  • Commodities
  • Companies
  • Cryptocurrencies
  • Economic Data
  • Economy
  • Editorials
  • Financial Education
  • Football
  • Forex
  • Industry
  • Investogist Business Saturday
  • Markets
  • News
  • Nigeria
  • Op-ed
  • Opinion & Analysis
  • Policies
  • Rates & Bonds
  • Sports
  • Stocks/Equities
  • Technology
  • Vacancies
  • World

Quick Links

  • News
  • Economy
  • Markets
  • Business
  • Opinion & Analysis
  • Travel & Tours

Newsletter

Copyright © 2020 investogist.com, All Rights Reserved

  • About Us
  • Terms & Conditions
  • Privacy Policy
  • Contact Us
No Result
View All Result
  • Home
  • News
    • Nigeria
    • Africa
    • World
  • Economy
    • Policies
    • Budgets
    • Economic Data
  • Markets
    • Stocks/Equities
    • Forex
    • Rates & Bonds
    • Commodities
    • Cryptocurrencies
  • Business
    • Companies
    • Industry
    • Technology
  • Sports
    • Football
  • Opinion & Analysis
    • Editorials
    • Book Club
    • Investogist Business Saturday
    • Op-ed
  • Financial Education
  • Vacancies

Copyright © 2021 investogist.com, All Rights Reserved

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist