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    UH Real Estate Investment Trust to distribute N5.05 per unit to unit holders

    Canceling Keystone XL pipeline cost thousands of jobs, billions of dollars – Biden Administration

    Breaking: President Joe Biden diagnosed with “aggressive” cancer

    Mexican Navy Ship crashes into New York Bridge

    Mexican Navy Ship crashes into New York Bridge

    Pope Leo XIV holds inaugural mass, sets tone for his papacy

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    Sunny Anene raises his stake in United Capital Plc

    Tantalizers PLC acquires Grand Media Projects Limited

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    Finland charges Simon Ekpa with inciting terrorism

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    President Donald Trump cancels protection for 500,000 Haitian migrants

    Spain golden visa scheme ends as Portugal and Greece demand increases

    Spain golden visa scheme ends as Portugal and Greece demand increases

    CBN fines nine banks 150 million Naira each for failing to dispense cash

    CBN ends free ATM withdrawals for other banks’customers

    FG increases private university application fee from N5m to N25m

    FG increases private university application fee from N5m to N25m

    United States scraps visa dropbox service for Nigerian applicants

    United States scraps visa dropbox service for Nigerian applicants

    Buhari says Nigeria security and economy improved during his tenure

    Buhari says Nigeria security and economy improved during his tenure

    Air Sierra Leone commences flight operations to Lagos

    Air Sierra Leone commences flight operations to Lagos

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    Nigeria renews $2 billion currency swap deal with China to boost bilateral trade

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    The Frontier Fund unit holders to get N17 per unit distribution

    Banks begin to charge taxes on bonds, T-bills as exemption expires

    Skyway Aviation Handling Company Plc announces N0.6 final dividend for 2024 FY

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    NGX Daily Equities Market Report: Market gains for third consecutive days

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    BITCOIN hits $103,000 for the first time

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    SEC approves Busha and Quidax as crypto exchanges in Nigeria

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    The Nigerian Stock Market: Has Tinubu’s Election impacted the Market Negatively?

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Home Opinion & Analysis Columnists

Important clue to rare inflammatory disease in children following COVID-19 infection

Wednesday, 18 August 2021, 7:52 pm
in Columnists, Opinion & Analysis
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Study reveals what triggers lung damage during COVID-19
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Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as a multisystem inflammatory syndrome in children or MIS-C.

The researchers reported that RNA sequencing of blood samples from the Mount Sinai COVID-19 Biobank led to the discovery that specific infection-fighting cells of the immune system are downregulated in children with MIS-C and that this is associated with a sustained inflammatory response, a hallmark of infection with SARS-CoV-2, the virus that causes COVID-19. The study was published in Nature Communications.

MIS-C is characterized by fever, pain and inflammation of multiple organs including the heart, lungs, kidneys, skin, eyes or gastrointestinal tract. More than 2600 cases MIS-C have been reported in the United State since the COVID-19 pandemic began. While an autoimmune condition has been suggested as an underlying cause, specific genes, pathways and cell types remain unknown. Through Mount Sinai’s extensive gene-expression study, the researchers have taken a significant step in providing the field with new exploratory pathways involving complex networks and subnetworks of genes they constructed from the Mount Sinai COVID-19 Biobank.

One of the more significant of these gene networks implicated the suppression of two types of immune cells: natural killer (NK) cells and CD8+T cells. Previous research has shown that when CD8+ T cells are persistently exposed to pathogens, they enter a state of “ exhaustion”, resulting in a loss of their effectiveness and ability to proliferate. The researchers in the new study specifically pointed to the CD8- T cells being in this exhausted state, thus potentially weakening the inflammatory immune response. An increase in NK cells is also associated with exhausted CD8+ T cells.

“Our study implicated T cells exhaustion in MIS-C patients as one of the potential drivers of this disease, suggesting that an increase in both NK cells and circulating exhausted CD8+ T cells may improve inflammatory disease symptoms,” says lead co-author Noam Beckmann, PhD, Assistant Professor of Genetics and Genomic Sciences, and member of the Mount Sinai Clinical Intelligence Center (MSCIC), at the Icahn School of Medicine at Mount Sinai. “Additionally we found nine key regulators of this network known to have an association with NK cell and exhausted CD8+ T cell functionality.”

  • Read also: Study reveals what triggers lung damage during COVID-19
  • No Sign of COVID-19-Vaccine in Breast Milk – Study

Dr. Beckmann adds that one of those regulators, TBX21, is a promising therapeutic target because it serves as a master coordinator of the transition of CD8+ T cells from effective to exhausted.

Mount Sinai’s work on MIS-C represents the first gene-expression study from the hospital’s COVID-19 Biobank. Created through the work of a volunteer team of more than 100 nurses, doctors, and researchers, the repository serves as the backbone of Mount Sinai’s rapidly expanding COVID-19 research. The team has collected blood samples from several hundreds of COVID-19 patients ( Including” longitudinal” or multiple samples from the same person) admitted to Mount Sinai’s hospital which, in turn, have generated a diverse set of molecular data yielding invaluable insight into better understanding and new therapeutic approaches to the diseases.

By: Peace Chigozie

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