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    Israel and Iran agree on ceasefire – Trump

    Israel and Iran agree on ceasefire – Trump

    Breaking: Iran launches missiles at US bases in the Middle East

    Breaking: Iran launches missiles at US bases in the Middle East

    US military strikes Iran

    US military strikes Iran

    EFCC seeks transfer of Orji Uzor Kalu’s trial to Lagos

    Yahoo boys launder money for ‘politically exposed persons’ – EFCC boss

    Gombe receives N60 billion from FG to establish Agro-Livestock Industrial Zone

    Gombe receives N60 billion from FG to establish Agro-Livestock Industrial Zone

    Student Loan Act: How to apply for the loan, all you need to know

    The increased prices of driver’s licenses, number plates set to take effect

    Trump congratulates Nigeria for Banning Twitter, says more countries should do same

    Trump bans citizens of 12 countries from entering the U.S, full list

    France launches mandatory online visa appointments for travelers

    France launches mandatory online visa appointments for travelers

    Federal Government declares June 6 and 9 public holidays

    Federal Government declares June 6 and 9 public holidays

    • Nigeria
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    • World
  • Economy
    • All
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    • Policies
    UK tightens visa rules for care workers, skilled workers and students

    UK tightens visa rules for care workers, skilled workers and students

    United States scraps visa dropbox service for Nigerian applicants

    President Donald Trump cancels protection for 500,000 Haitian migrants

    Spain golden visa scheme ends as Portugal and Greece demand increases

    Spain golden visa scheme ends as Portugal and Greece demand increases

    CBN fines nine banks 150 million Naira each for failing to dispense cash

    CBN ends free ATM withdrawals for other banks’customers

    FG increases private university application fee from N5m to N25m

    FG increases private university application fee from N5m to N25m

    United States scraps visa dropbox service for Nigerian applicants

    United States scraps visa dropbox service for Nigerian applicants

    Buhari says Nigeria security and economy improved during his tenure

    Buhari says Nigeria security and economy improved during his tenure

    Air Sierra Leone commences flight operations to Lagos

    Air Sierra Leone commences flight operations to Lagos

    Nigeria renews $2 billion currency swap deal with China to boost bilateral trade

    Nigeria renews $2 billion currency swap deal with China to boost bilateral trade

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    MTN Nigeria to pay over N200 billion final dividend for 2022

    List of Dividends announced in 2025, qualification and payment dates

    Sovereign Trust Insurance Plc grows Profit after tax by 43%  in Q1 2021

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    Dangote Petroleum Refinery to begin distribution of PMS and Diesel nationwide

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    United Capital Group expands into Francophone West Africa

    List of Dividends announced in 2024, qualification and payment dates

    Cornerstone Insurance Plc to pay 27 kobo final dividend for 2024 FY

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    Legend Internet Plc reports N32.9 million profit for Q1 2025

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    ELECTION: Cutix Plc reschedules Board Meeting

    Weekly Report: Nigerian Exchange sees mixed performance as Cutix Plc emerge top gainer

    Again DMO offers N360 billion FGN bond for February

    DMO offers N300 billion FGN bond for auction in May

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    CSCS Plc explores listing on the Nigerian Exchange (NGX)

    NGX Daily Equities Market Report: Market gains for third consecutive days

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    Bitcoin soars above $21,000 as U.S. dollar sags

    BITCOIN hits $103,000 for the first time

    Bitcoin (BTC) rises above US$90,000 records a new all time high

    Bitcoin (BTC) rises above US$90,000 records a new all time high

    Bitcoin crosses US$60K, approaches All-Time High

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    Rovina Medical Diagnostic Services offers free Breast and Prostrate cancer scans

    Rovina Medical Diagnostic Services offers free Breast and Prostrate cancer scans

    Security features of the new naira notes revealed by the CBN

    New hope for Naira fixed income savers?

    The Nigerian Stock Market: Has Tinubu’s Election impacted the Market Negatively?

    Nigerian Exchange gains 5.37% in Tinubu’s first week, highest for any President since return to Democracy

    The Nigerian Stock Market: Has Tinubu’s Election impacted the Market Negatively?

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Home Opinion & Analysis Columnists

Targeted Therapy could be First-Line Treatment for Childhood Cancer

Sunday, 27 June 2021, 3:07 pm
in Columnists, Opinion & Analysis
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Targeted Therapy could be First-Line Treatment for Childhood Cancer
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Scientists studying a common Childhood Cancer have made a major breakthrough that could lead to a cure for some youngsters who would not have survived the condition.

An international study, involving Newcastle University, UK, has for the first time found a genetic marker in tumours from patients with high-risk neuroblastoma.

Research published in the journal of clinical oncology has identified that alterations in the neuroblastoma’s ALK ( anaplastic lymphoma kinase) gene are associated with a significantly poorer prognosis for children with high-risk disease.

Experts say that identifying this important genetic marker means patients should be put on ALK inhibitor at the time of diagnosis with the hope of a cure.

Personalized treatment:

Professor, Deborah Tweddle, from the Newcastle University Center for Cancer and Honorary Consultant at the Newcastle Hospital NHS Foundation Trust, led the UK part of the study.

Read also: New findings Offer Improved Therapy of Early Stage, BRCA mutations – associated Breast Cancer

She said, “ By identifying ALK as a genetic marker associated with the likelihood of a poorer outcome within the high-risk group of patients, it means we can treat these patients differently from the outset”.

“  Most excitingly there are new treatments that target the ALK protein itself, used in other cancer that can now be used for patients with high-risk neuroblastoma with ALK gene abnormalities”.

“ This research is an excellent example of personalized medicine, by treating those patients with an ALK genetic abnormality with an ALK inhibitor, we are tailoring the treatment to the patient’s individual tumour type”.

“ By combining an ALK inhibitor with the other treatment we currently give for high-risk neuroblastoma, we hope to be able to cure more patients with this aggressive childhood cancer”.

Neuroblastoma is a cancer of the nervous system that mainly affects children under five, it often begins in the adrenal gland, but in around half of the cases has spread throughout the body when it is diagnosed, despite treatment including high dose chemotherapy, surgery, radiotherapy and immunotherapy.

Several European countries took part in the study and the UK- arms of the trial have been based at Newcastle University with the test being carried out with the Newcastle Genetic Lab, supported by Grant from Solving Kids Cancer and Neuroblastoma UK.

Study’s findings:

Experts carried out ALK testing on as many Neuroblastoma as possible from patients treated on the high-risk trial and pooled this data with that from National Genetic Labs from 19 other countries.

The study showed that ALK mutations are present in about 14 per cent of patients newly diagnosed with high-risk neuroblastoma, and nearly 14 per cent have amplification of this gene.

More importantly, these abnormalities are associated with a lower rate of survival and they are therefore important prognostic markers that could be targeted by treatment.

“As part of the next European Clinical Trial for high-risk neuroblastoma, we are going to treat all patients with an ALK abnormality found in their tumour with an ALK inhibitor in addition to standard treatment”, Professor Tweddle added.

The breakthrough comes at the launch of the Newcastle University Cancer Fund, a new fundraising efforts to inspire the next generation of cancer researchers to train and work at Newcastle for the benefits of people living with cancer locally as well as sending their research worldwide.

The fund will work with cancer researchers at the very earliest stages of their studies and see them through to the point where they become established cancer researchers.

By: Peace Chigozie

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