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    Tinubu signs Electricity Act of 2023; States to generate, transmit and distribute electricity

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    • All
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    Headline Inflation in Nigeria rose to 22.04% in March

    Food prices continue to soar in Nigeria as inflation hits 25.80%

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    Student Loan Act: How to apply for the loan, all you need to know

    FG establishes ‘Infrastructure Support Fund (ISF) for the 36 States of the Federation’

    Headline Inflation in Nigeria rose to 22.04% in March

    Inflation in Nigeria rises to 22.79% in June 2023

    CBN extends Naira 4 Dollar Scheme for diaspora remittances until further notice

    CBN includes Naira as payout option for diaspora remittance

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    The NGX- ASI gained by 1.11% as Dangote Sugar rises another 10%

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    Equities Market Recorded Gains… As NGX-ASI Grows Marginally By 0.02%

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    Nigerian Exchange gains 5.37% in Tinubu’s first week, highest for any President since return to Democracy

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Home Opinion & Analysis Columnists

Common weight- loss drug successfully targets fat that can endanger heart health

Thursday, 5 August 2021, 7:42 am
in Columnists, Opinion & Analysis
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Common weight- loss drug successfully targets fat that can endanger heart health
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Researchers at UT Southwestern announced successful results of a clinical trial for a commonly prescribed weight-loss drug called liraglutide. In adults who are overweight or have obesity combined with high cardiovascular risk, once-daily liraglutide combined with lifestyle interventions significantly lowered two types of fat that have been associated with a risk to heart health: visceral fat and ectopic fat.

“Our study used the latest imaging technology to evaluate different fat components in the body. The main finding was a significant decrease in visceral fat in patients without diabetes but who were overweight or had obesity. These results show the potential of liraglutide treatment for significantly lowering the risk of chronic disease in this population,” said Parag Joshi, M.D., preventive cardiologist, Assistant Professor of Cardiology, and senior author of the study published in The Lancet Diabetes and Endocrinology.

Visceral fat is stored within the abdominal cavity around important internal organs, such as the liver, pancreas, and intestines. Ectopic fat is stored in tissue that normally contains small amounts of fat, such as the liver, skeletal muscle, heart and pancreas.

The 185 study participants were given a once-daily injection of liraglutide over 40 weeks of treatment. The relative effects of liraglutide on fat reduction were two-fold greater in the abdominal tissue and six-fold greater in the liver than seen on overall body weight. The treatment effects were consistent across race/ ethnicity and BMI categories, and among those with or without baseline prediabetes. Liraglutide also reduced fasting blood glucose and inflammation in the trial population without diabetes, the majority of whom had normal blood sugar levels at baseline.

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In a 2016 study led by UTSW investigators called the Leader trial, the rate of the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke among patients with type 2 diabetes was lower in those treated with liraglutide than with placebo. “Our findings help add a possible mechanism for why there is a benefit of liraglutide on the cardiovascular outcome while also showing its benefits in people without diabetes,” said Dr. Joshi.

According to the researchers, obesity affects an estimated 1 in every 4 adults and 1 in every 5 youths, leading to a substantial risk of cardiovascular disease and mortality. “Excess visceral fat and ectopic  ( e.g. liver) fat are central to the development of type 2 diabetes and cardiovascular disease,” said Dr. Joshi. “It remains challenging to identify those at highest risk, in order to offer them treatment in addition to lifestyle changes such as diet and exercise.”

By: Peace Chigozie.

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